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Accelerated Clearance of Carbon Monoxide by Normocapnic Hyperpnea in Human Subjects
Prehospital and Disaster Medicine
The rate of carbon monoxide (CO) elimination is increased by CO 2 -stimulated ventilation in CO poisoned, unconscious dogs. However, most conscious humans are unlikely to tolerate prolonged breathing of 5-10% CO 2 . We proposed to determine: 1) the effect on the half-time of carboxyhemoglobin (COHb) elimination (Tj/ 2 ) of a voluntary increase in ventilation of approximately 5 times from resting levels with FjO 2 = 100%); 2) whether this level of hyperpnea is sustainable long enough to providedoi:10.1017/s1049023x00034713 fatcat:u3ghcfjy6bbohfrttnvblyapfe