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In asthma the following clinical observations have been made : 1. Low pulse pressure in those cases uncomplicated by arteriosclerosis, probably due to diminished systolic volume. 2. Loud pulmonic second sound pointing towards increased resistance in the lesser circulation. 3. Polycythemia, possibly a teleologic phenomenon designed to compensate for a lessened minute volume output from the left ventricle.doi:10.1001/archinte.1917.00080240086006 fatcat:qsruikhxfvchharftacmmb2rum