Pelletization by Extrusion-Spheronization: A detailed review Pelletization by Extrusion-Spheronization-A detailed review

Nagasamy Dhandapani, Ayush Shrestha, Niroj Shrestha, Anup Thapa, Goti Sandip, Rajan Sharma, Bhattarai, Nagasamy Dhandapani, Ayush Shrestha, Niroj Shrestha, Anup Thapa, Goti Sandip (+2 others)
2012 All Res. J. Biol   unpublished
Oral multiparticulate drug systems (e.g. pellets, granules) in comparison to single unit dosage forms offer biopharmaceutical advantages in terms of more even and predictable drug distribution in the enteric system. Extrusion spheronization is one of the most commonly used techniques in the formulation of such multiparticulate beads and pellets providing sustained and controlled release or modified release drug delivery. This review outlines the various steps involved in the extrusion
more » ... tion process, the excipients used in such formulations along with some modifications and various processing variables affecting the quality of pellets formed. In addition, an overview of the methods available for the quality check of the pellets is reviewed.
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