TINOSPORA CORDIFOLIA (MIERS) EXTRACT PROVIDES PROTECTION AGAINST RADIATION INDUCED ALTERATIONS IN INTESTINAL MUCOSA OF SWISS ALBINO MOUSE

Sunita Arya, Jaimala Sharma
unpublished
Intestinal protection in mice against radiation injury by Tinospora cardifolia (TC)(5mg/kg/body weight/day) was studied from day ¼ to days 30 after whole body gamma radiation (6 Gy and 8 Gy). Villus length, goblet cells/villus Section/crypt Section, total cell population/villus or crypt Section, mitotic cells/crypt Section of jejunum are good parameters for the assessment of radiation damage. There was significant decrease in the villus length, total cell population and mitotic cells, whereas
more » ... ic cells, whereas goblet cell count significantly increased after irradiation. Tinospora cordifolia pretreatment resulted in a significant increase in villus length, total cell population and mitotic cells, whereas goblet cells were lesser than those which were irradiated without TC at each autopsy day. The results suggest that Tinospora cordifolia pretreatment provides protection against radiation induced alterations in intestinal mucosa of swiss albino mouse.
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