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Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein
2017
Nature
Glucagon-like peptide-1 (GLP-1) is a hormone with essential roles in regulating insulin secretion, carbohydrate metabolism and appetite. GLP-1 effects are mediated through binding to GLP-1R, a family B G protein-coupled receptor (GPCR) signaling primarily through the stimulatory G protein Gs. Family B GPCRs are important therapeutic targets, however our understanding of their mechanism of action is limited by the lack of structural information on activated and full-length receptors. Here we
doi:10.1038/nature22394
pmid:28538729
pmcid:PMC5587415
fatcat:cyx2nqh5o5gbfnfev5lnnx3dsu