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Decreased Overall Virulence in Coinfected Hosts Leads to the Persistence of Virulent Parasites
Multiple infections are known to affect virulence evolution. Some studies even show that coinfections may decrease the overall virulence (the disease-induced mortality of a coinfected host). Yet, epidemiological studies tend to overlook the overall virulence, and within-host models tend to ignore epidemiological processes. Here, I develop an epidemiological model where overall virulence is an explicit function of the virulence of the coinfecting strains. I show that in most cases, a uniquedoi:10.1086/588077 pmid:18582168 fatcat:wmfvxqxw2ffqxgrmrmh2z3k5yy