Phosphate Depletion Induced by the Usual Dose of an Antacid

Yoshinobu KOIDE, Kumiko ISHII, Nobuo KUGAI, Setsuko INOUE, Michio IMAWARI, Nobuaki KUZUYA, Mitsuo ITAKURA, Toshiro FUJITA, Koichi KAWAI, Kamejiro YAMASHITA
1986 Japanese Journal of Bone and Mineral Metabolism  
A 72-yearold diabetic woman taking 1.3g of Al(OH)3 daily for 3 months was evaluated for bone pain, anorexia, and weakness. Laboratory studies disclosed hyohosatemia, hypophosphaturia, bypercalciuria, high% tubular reabsorption of phosphate, suppressed immunoloical parathyroid hormone, and high alkaline phospatase levels. Radiological examinations demonstrated generalized osteoenia and multiple compression fractures. Biochemical abnormalities and clinical symptoms disappeared soon after
more » ... uing the antacid. Phosphate tolerance test performed 8 months later disclosed normal renal phosphate handling but the impaired intestinal phosphate absorption with low plasma 1, 25(OH)2D3 level. Physicians should be cautious for hypopspatemia when prescribing even the usual dose of antacid to patients who might have low serum 1, 25(OH)2D3 level.
doi:10.11393/jbmm1983.4.7 fatcat:wesom7d6ujbh3iuwtsjubbrhiu