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Ways for vaccines improvment are described. WHO criteria and domestic requirements for influenza vaccines quality are presented. The multicenter, double-blind, randomized trial in parallel groups of the first Russian quadrivalent vaccine is described in details. Multicenter study for assessment of vaccine safety, reactogenicity and immunogenicity was performed in 612 volunteers aged 18-60 years in the epidemic season 2016-2017.. In the study conducted , it was demonstrated that the firstdoaj:1eebb40c1ab24e4b9e15ff400b96b12f fatcat:3wahsjqop5hu7hj2uolajxlrxa