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The Role of Corticotropin-Releasing Factor Receptors in Stress and Anxiety
2002
Integrative and Comparative Biology
SYNOPSIS. Corticotropin releasing factor (CRF) is a critical integrator of the hypothalamic-pituitary-adrenal (HPA) axis in response to stress. CRF and its related molecule urocortin (UCN) bind CRF receptor 1 (CRFR1) and CRFR2 with distinct affinities. Mice deficient for CRFR1 or CRFR2 were generated in order to determine the physiological role of these receptors. While CRFR1-mutant mice show a depleted stress response and display anxiolytic-like behavior, CRFR2-mutant mice are hypersensitive
doi:10.1093/icb/42.3.552
pmid:21708750
fatcat:sbtkyz6upjenbktn2p7jsmkq54