Conclusions: The obtained results have shown the possible relation between the GSTT1 genotype and the level of chromosome aberrations in somatic cells of lung cancer patients. P2-141 BSTB: Tumor and Cell Biology Posters, Tue, Sept 4 Antitumor effect of antibody against a novel antigen (UOEH-LC-1) on lung cancer xenotransplanted into SCID mice Background: The clinical application of monoclonal antibodies has been well established for the treatment of various human cancers. However, there were a

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... ew reports which showed the effectiveness of antibody therapy against lung cancer. In the present study, we report a novel cell surface antigen which was identified by SEREX method by using the antibody (Ab) derived from tumor-infiltrating B lymphocytes (TIB). Methods: A904L, a lung large cell carcinoma cell line, was established from patient A904. The surgically resected lung cancer specimens of the patient was xenotransplanted into SCID mice. SCID mice engrafted with the lung cancer were bled by retro-orbital venipuncture every 2 weeks and the amount of human immunoglobulin produced from TIB