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Local Ras activation, PTEN pattern, and global actin flow in the chemotactic responses of oversized cells
Journal of Cell Science
Chemotactic responses of eukaryotic cells require a signal processing system that translates an external gradient of attractant into directed motion. To challenge the response system to its limits, we increased the size of Dictyostelium discoideum cells by using electric-pulse-induced fusion. Large cells formed multiple protrusions at different sites along the gradient of chemoattractant, independently turned towards the gradient and competed with each other. Finally, these cells succeeded todoi:10.1242/jcs.191148 pmid:27505897 fatcat:656rwtjk7vepzoiy5b6mmaoic4