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Simple, precise and accurate method is described for the direct determination of Levofloxacin hemihydrate and Cefpodoxime proxetil in combined dosage form without prior separation. The method was based on HPTLC separation of the two drugs followed by the densitometry measurements of their spots at 237 nm for both drugs. The separation was carried out on silica gel 60GF254 using mobile phase Butanol: Ethyl Acetate: hexane: triethylamine(2:6:4:0.1).The linearity for Levofloxacin hemihydrates andfatcat:khgtq2rwefabdlpkrwv3l2n7cq