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Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophages
[article]
2020
bioRxiv
pre-print
In order to replicate, the Human Immunodeficiency Virus (HIV-1) reverse transcribes its RNA genome into DNA, which subsequently integrates into host cell chromosomes. These two key events of the viral life cycle are commonly viewed as separate not only in time but also in cellular space, since reverse transcription (RT) is thought to be completed in the cytoplasm before nuclear import and integration. However, the spatiotemporal organization of the early replication cycle in macrophages,
doi:10.1101/2020.04.12.038067
fatcat:pcoyx2sbqjga5izurz4sbcfgfy