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Extracellular matrix metabolism disorder induced by mechanical strain on human parametrial ligament fibroblasts
2017
Molecular Medicine Reports
Pelvic organ prolapse (POP) is a global health problem that may seriously impact the quality of life of the sufferer. The present study aimed to investigate the potential mechanisms underlying alterations in extracellular matrix (ECM) metabolism in the pathogenesis of POP, by investigating the expression of ECM components in human parametrial ligament fibroblasts (hPLFs) subject to various mechanical strain loads. Fibroblasts derived from parametrial ligaments were cultured from patients with
doi:10.3892/mmr.2017.6372
pmid:28339064
fatcat:bsglypcstzhsjkuvtqf2nqkuou