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Cripto-1 plasmid DNA vaccination targets metastasis and cancer stem cells in murine mammary carcinoma
Cancer immunology research
Metastatic breast cancer is a fatal disease that responds poorly to treatment. Cancer vaccines targeting antigens expressed by metastatic breast cancer cells and cancer stem cells could function as anticancer therapies. Cripto-1 is an oncofetal protein overexpressed in invasive breast cancer and cancer-initiating cells. In this study, we explored the potential of a Cripto-1-encoding DNA vaccine to target breast cancer in preclinical mouse models. BALB/c mice and BALB-neuT mice were treated withdoi:10.1158/2326-6066.cir-17-0572 pmid:30143536 fatcat:yt3eoqaamrd45g5m6bhqtt52lm