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Structural Determination of Rat and Dog Urinary Metabolites of a New Antidepressant RS-8359
新規抗うつ薬RS‐8359のラットおよびイヌ尿中代謝物の構造決定
1998
Drug Metabolism and Pharmacokinetics
新規抗うつ薬RS‐8359のラットおよびイヌ尿中代謝物の構造決定
Preserved Fulltext
RS-8359 is a selective and reversible inhibitor of A type monoamine oxidase. In order to eluci date the metabolism of RS-8359, the metabolites were isolated from the urine after oral administration to rats and dogs. The chemical structures of the seven isolated metabolites, including the unchanged form, were determined by NMR and mass spectrometry. Hydroxylation on the cyclopentanol moiety and oxidation on the pyrimidine moiety of the molecule were preferentially responsible for the phase I
doi:10.2133/dmpk.13.351
fatcat:mboqtqfzwje5dh3i7ke6347apy