The Coagulant and Thrombogenic Properties of Human Atheroma

CHARLES L. LYFORD, WILLIAM E. CONNOR, JOHN C. HOAK, EMORY D. WARNER
<span title="">1967</span> <i title="Ovid Technologies (Wolters Kluwer Health)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yp7myvwge5ef7jsub32vmdbdhy" style="color: black;">Circulation</a> </i> &nbsp;
Suspensions of gruel from severely atherosclerotic human aortas and coronary arteries were tested in several coagulation systems. The atheromatous material shortened the clotting time of normal whole blood and plasma and accelerated thrombus formation time in the Chandler apparatus. Normal human platelets in platelet-rich plasma were aggregated by the atheromatous gruel. Aggregation did not occur when the gruel was added to platelet-rich plasma from a patient with a severe factor XII (Hageman)
more &raquo; ... eficiency. The intravenous injection of atheromatous plaque suspensions into rats caused thrombocytopenia, shortening of the whole blood clotting time, and thrombosis. Coagulation of blood from patients with classical hemophilia, with Hageman factor deficiency, and with coumarin-induced anticoagulant effect was accelerated by the addition of the atheromatous gruel. Blood from patients given heparin, however, largely retained its anticoagulant activity. Atheromatous material from both aortic and coronary arteries behaved similarly in the systems tested. The coagulant and platelet clumping properties of atheromatous plaques may be related to their content of fatty acids, phospholipids, collagen, or thromboplastin. Additional Indexing Words: Coronary artery Aorta Blood coagulation Mural thrombosis T HROMBOSIS is a complication of atherosclerosis that frequently leads to arterial occlusion and subsequent organ infarction.2 3 This complication is more likely to occur in an atherosclerotic artery when the endothelial surface has been disrupted.4 5 When an atherosclerotic plaque ulcerates, its
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