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Let-7 derived from endometrial extracellular vesicles is an important inducer of embryonic diapause in mice
Embryonic diapause is a maternally controlled phenomenon. The molecule controlling the onset of the phenomenon is unknown. We demonstrated that overexpression of microRNA let-7a or incubation with let-7g–enriched extracellular vesicles from endometrial epithelial cells prolonged the in vitro survival of mouse blastocysts, which developed into live pups after having been transferred to foster mothers. Similar to in vivo dormant blastocysts, let-7–induced dormant blastocysts exhibited low leveldoi:10.1126/sciadv.aaz7070 pmid:32917695 fatcat:6viwtpjgxvajjndilte7tc4oqm