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A sublineage of the Delta variant, AY.4.2, recently accounted for an increase proportion of Delta cases in United Kingdom (UK), Romania, Poland, and Denmark. Several factors may account for the increased spread of AY.4.2. Here, we evaluated the sensitivity of AY.4.2 to neutralisation by sera from Pfizer/BioNTech (BNT162b2) vaccinees. AY.4.2 was not more resistant to neutralisation relative to other circulating Delta lineages or sublineages and showed only a modest 2.3-fold reduction indoi:10.1101/2021.11.08.21266075 fatcat:r5hxnje6o5fprjkxba2qc4giyi