Neutralisation of SARS-CoV-2 Delta sub-lineage AY.4.2 and B.1.617.2+E484K by BNT162b2 mRNA vaccine-elicited sera [article]

Ria Lassauniere, Charlotta Polacek, Jannik Fonager, Marc Bennedbaek, Lasse Boding, Morten Rasmussen, Anders Fomsgaard
2021 medRxiv   pre-print
A sublineage of the Delta variant, AY.4.2, recently accounted for an increase proportion of Delta cases in United Kingdom (UK), Romania, Poland, and Denmark. Several factors may account for the increased spread of AY.4.2. Here, we evaluated the sensitivity of AY.4.2 to neutralisation by sera from Pfizer/BioNTech (BNT162b2) vaccinees. AY.4.2 was not more resistant to neutralisation relative to other circulating Delta lineages or sublineages and showed only a modest 2.3-fold reduction in
more » ... ation relative to the vaccine strain. In contrast, the more rare B.1.617.2+E484K variant showed a 4.2-fold reduction in neutralisation that warrants surveillance of strains with the acquired E484K mutation.
doi:10.1101/2021.11.08.21266075 fatcat:r5hxnje6o5fprjkxba2qc4giyi