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Accurate and Efficient Estimation of Small P-values with the Cross-Entropy Method: Applications in Genomic Data Analysis
[article]
2018
arXiv
pre-print
Small p-values are often required to be accurately estimated in large scale genomic studies for the adjustment of multiple hypothesis tests and the ranking of genomic features based on their statistical significance. For those complicated test statistics whose cumulative distribution functions are analytically intractable, existing methods usually do not work well with small p-values due to lack of accuracy or computational restrictions. We propose a general approach for accurately and
arXiv:1803.03373v2
fatcat:hlbtjqfh4ndf5hbk3d2aeytnxq