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Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Deficit Hyperactivity Disorder (ADHD)

A.J. Russo
2010 Journal of Central Nervous System Disease  

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Aim: To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in children with ADHD and evaluate its possible relationship to Cu and Zn levels. Subjects and methods: Serum from 22 children with ADHD and 20 healthy control children without ADHD and 19 autistic children without ADHD were tested for Cu/Zn SOD using ELISAs and levels of serum Cu and Zn using inductively-coupled plasma-mass spectrometry. Results: Serum Cu/Zn SOD levels of ADHD children were significantly lower than age and
more » ... er matched healthy non-ADHD controls (P 0.001). Serum Cu/Zn SOD of ADHD children was significantly lower in individuals with high serum copper (P 0.024). There was no significant correlation between Cu/Zn SOD levels and Zinc or Cu/Zn in ADHD individuals. Discussion: These results suggest an association between Cu/Zn SOD serum levels and ADHD, particularly ADHD children with high serum copper.
doi:10.4137/jcnsd.s4553 fatcat:5aulzn7t3ff5jk4zoifl4vryxa
DOAJ
Citation

A.J. Russo. "Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Deficit Hyperactivity Disorder (ADHD)." Journal of Central Nervous System Disease (2010) JCNSD.S4553