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As scientific publication rates increase, knowledge acquisition and the research development process have become more complex and time-consuming. Literature-Based Discovery (LBD), supporting automated knowledge discovery, helps facilitate this process by eliciting novel knowledge by analysing existing scientific literature. This systematic review provides a comprehensive overview of the LBD workflow by answering nine research questions related to the major components of the LBD workflow (i.e.,doi:10.7717/peerj-cs.235 pmid:33816888 pmcid:PMC7924697 fatcat:w3gat4llvfarhbjo2gpfgt4smi