ACTILIFE TABLET AND GREEN TEA EXTRACT ACT SYNERGISTICALLY TO PROTECT RAT LIVER AGAINST PARACETAMOL TOXICITY

Vengal Pachava, Praveen Thaggikuppe Krishnamurthy, L Ramanathan, G Sivaraman, S Vishagan, S Madhavan
2017 unpublished
In the present study protective effect of Actilife tablets (AT) and Green tea extract (GTE) against paracetamol induced hepatotoxicity was evaluated individually and in combination. Rats are pretreated with AT (50 and 100 mg/kg, p.o), GTE (5 and 10 mg/kg, p.o), and combination formulation, ATG (40 and 80 mg/kg, p.o), for 14 days. On day 14 paracetamol was administered (2.5 g/kg, p.o) and after 48 h serum was analyzed for ASAT, ALAT, ALP and TP. The liver tissue was analyzed for SOD, catalase,
more » ... H, GPx, MDA and histopathology. AT, GTE and ATG show a dose dependent protection against the paracetamol induced changes in serum and liver tissue parameters(p<0.05). When compared to AT and GTE, the combination formulation, ATG, shows a superior hepatoprotection even at doses below their individual equivalent doses. The results, therefore indicate synergism between the ingredients of AT and GTE. PhOL Pachava, et al. 121 (pag 120-129)
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