Reliability and Validity of Noninvasive Imaging of Internal Carotid Artery Pseudo-Occlusion

G. Furst, A. Saleh, F. Wenserski, J. Malms, M. Cohnen, A. Aulich, T. Neumann-Haefelin, M. Schroeter, H. Steinmetz, M. Sitzer
1999 Stroke  
and Purpose-Our study evaluated noninvasive tests for the diagnosis of atheromatous internal carotid artery (ICA) pseudo-occlusion. Methods-Twenty patients (17 men, 3 women; mean age ϮSD, 64.3Ϯ11.6 years) with angiographically proven atheromatous ICA pseudo-occlusion (20 vessels) were prospectively examined with MR angiography (MRA; 2D and 3D time-of-flight techniques), color Doppler-assisted duplex imaging (CDDI) and power-flow imaging (PFI) with and without an intravenous ultrasonic contrast
more » ... gent. As a control group, 13 patients (13 men; meanϮSD age, 63.0Ϯ9.0 years) with angiographically proven ICA occlusion (13 vessels) were studied with the same techniques. For the determination of interobserver agreement ( statistics), the findings of each diagnostic technique were read by 2 blinded and independent observers who were not involved in patient recruitment and initial data acquisition. Specificity and sensitivity were calculated for all noninvasive techniques (observer consensus) in comparison to the standard of reference (intra-arterial angiography). Results-Interobserver reliabilities were ϭ0.86 for intra-arterial angiography, ϭ0.90 for unenhanced CDDI, ϭ0.93 for enhanced CDDI, ϭ0.93 for unenhanced PFI, ϭ1.0 for enhanced PFI, ϭ0.93 for 2D MRA, and ϭ0.77 for 3D MRA, respectively (PϽ0.0001). Specificities and sensitivities were 0.92 and 0.70 for unenhanced CDDI, 0.92 and 0.83 for enhanced CDDI, 0.92 and 0.95 for unenhanced PFI, 1.0 and 0.94 for enhanced PFI, 1.0 and 0.65 for 2D MRA, and 0.89 and 0.47 for 3D MRA, respectively. Conclusions-Advanced ultrasonographic techniques, especially PFI (with only 1 false-positive diagnosis of occlusion in the present series), can provide reliable and valid data to differentiate between ICA pseudo-occlusion and complete occlusion. In contrast, time-of-flight MRA at its present state is not capable of predicting minimal residual flow within a nearly occluded ICA. (Stroke. 1999;30:1444-1449.)
doi:10.1161/01.str.30.7.1444 pmid:10390321 fatcat:lfrpklnbl5gtdl54nvir3w3wxe