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This study examines the influence of chronic retroviral infection of mice with a LPBM5 virus mixture on the paracrine system involving immune cells and 1,25-(OH) 2 D 3 in the spleen. Plasma ionized calcium, 25-(OH)D and 1,25-(OH) 2 D of infected mice were unchanged. In contrast, the specific binding of 1,25-(OH) 2 D 3 to spleen cytosol and the number of monocyte/macrophages expressing 1,25-(OH) 2 D 3 receptors (VDR) were markedly increased. The retroviral infection also influenced the localdoi:10.1210/endo.138.12.5582 pmid:9389537 fatcat:gf3zsd3irbh7jducfjh53n2efq