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The Effect of Isoflurane on Neutrophil Selectin and β2-Integrin Activation In Vitro
Anesthesia and Analgesia
Isoflurane is reported to reduce ischemia-reperfusion injury. Lower expression of CD11b may be responsible for attenuated postischemic neutrophil adhesion to vascular endothelium. However, neutrophil adhesion to vascular endothelium is a multistep process involving several selectins and ␤ 2 -integrins. Therefore, we assessed whether isoflurane affects the activation of the selectins P-selectin glycoprotein ligand-1 (PSGL-1) and L-selectin and the ␤ 2 -integrins CD11a and CD11b. Whole blood wasdoi:10.1097/00000539-200209000-00017 pmid:12198042 fatcat:st3atsbyxvf5nktm7so5lc76xq