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CopulaNet: Learning residue co-evolution directly from multiple sequence alignment for protein structure prediction
[article]
2020
bioRxiv
pre-print
Protein functions are largely determined by the final details of their tertiary structures, and the structures could be accurately reconstructed based on inter-residue distances. Residue co-evolution has become the primary principle for estimating inter-residue distances since the residues in close spatial proximity tend to co-evolve. The widely-used approaches infer residue co-evolution using an indirect strategy, i.e., they first extract from the multiple sequence alignment (MSA) of query
doi:10.1101/2020.10.06.327585
fatcat:ibaqr2pwivhvjfsrcpqctuocoi