Effect of Curcumin on Hippocampal Levels of Brain-Derived Neurotrophic Factor and Serum Levels of Inflammatory Cytokines in Rat Model for Alzheimer's Disease

Damoon Sadoughi, Jina Khayatzadeh
2018 The Neuroscience Journal of Shefaye Khatam  
Alzheimer's disease (AD) is a progressive neurodegenerative disease of the central nervous system. Neuronal injury and oxidative stress in AD increases the level of inflammatory cytokines. Curcumin has antioxidant and neuroprotective properties. The aim of this study was to determine the effect of curcumin on hippocampal levels of brain-derived neurotrophic factor (BDNF) and serum levels of inflammatory cytokines in an experimental model of AD. Materials and Methods: 28 male rats divided into 4
more » ... rats divided into 4 groups: Control group (30 days, intraperitoneal injection of DMSO), AD control group (30 days, intraperitoneal injection of DMSO, after induction of AD) and two AD treatment groups with application of 50 and 100 mg/kg of curcumin (30 days, intraperitoneal injection of curcumin, after induction of AD). AD was induced by intraperitoneal injection of 8 mg/kg trimethyltin chloride. At the end of the treatment period, the hippocampal levels of BDNF and serum levels of different cytokines (TNF-α, IL-1β and IL-6) were measured by ELISA method. Results: Compared to AD control group, administration of curcumin with dose of 100 mg/kg significantly increased the hippocampal levels of BDNF (P=0.002) and decreased the serum levels of TNF-α, IL-1β and IL-6 (P=0.001). Conclusion: Administration of curcumin may decrease the serum levels of inflammatory cytokines in AD, possibly via enhancement of the hippocampal levels of BDNF. This study suggests the protective effect of curcumin against neuronal damages and oxidative stress in AD. ‫االيزا‬ ‫روش‬ ‫توسط‬ )IL-6 ,IL-1β ,TNF-α( ‫مختلف‬ ‫هاي‬ ‫سايتوکین‬ ‫سطح‬ ‫در‬ ‫داري‬ ‫معني‬ ‫افزايش‬ ‫کیلوگرم‬ ‫بر‬ ‫گرم‬ ‫میلي‬ 100 ‫دوز‬ ‫با‬ ‫کورکومین‬ ‫تجويز‬ ‫آلزايمري،‬ ‫شاهد‬ ‫گروه‬ ‫با‬ IL-6 ‫و‬ IL-1β ،TNF-α ‫سرمي‬ ‫سطح‬ ‫کاهش‬ ‫و‬ )P=0/002( ‫مغز‬ ‫از‬ ‫مشتق‬ ‫نوروتروفیك‬ ‫فاکتور‬ ‫هیپوکامپي‬ ‫هاي‬ ‫سايتوکین‬ ‫سرمي‬ ‫سطح‬ ‫کاهش‬ ‫با‬ ‫است‬ ‫ممکن‬ ‫کورکومین‬ ‫تجويز‬ ‫گيري:‬ ‫نتيجه‬ ‫داشت.‬ )P=0/001( ‫اين‬ ‫شود.‬ ‫مغز‬ ‫از‬ ‫مشتق‬ ‫نوروتروفیك‬ ‫فاکتور‬ ‫هیپوکامپي‬ ‫سطح‬ ‫افزايش‬ ‫موجب‬ ‫آلزايمر،‬ ‫بیماري‬ ‫در‬ ‫التهابي‬ ‫پیشنهاد‬ ‫را‬ ‫آلزايمر‬ ‫بیماري‬ ‫در‬ ‫اکسیداتیو‬ ‫استرس‬ ‫و‬ ‫نوروني‬ ‫هاي‬ ‫آسیب‬ ‫علیه‬ ‫کورکومین‬ ‫محافظتي‬ ‫اثر‬ ‫مطالعه‬ ‫دهد.‬ ‫مي‬
doi:10.29252/shefa.6.1.1 fatcat:4qhrk65jvndprk6iri3mzyaif4