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Molecular Determinants of Substrate Recognition in Hematopoietic Protein-tyrosine Phosphatase
2004
Journal of Biological Chemistry
The extracellular signal-regulated protein kinase 2 (ERK2) plays a central role in cellular proliferation and differentiation. Full activation of ERK2 requires dual phosphorylation of Thr 183 and Tyr 185 in the activation loop. Tyr 185 dephosphorylation by the hematopoietic protein-tyrosine phosphatase (HePTP) represents an important mechanism for down-regulating ERK2 activity. The bisphosphorylated ERK2 is a highly efficient substrate for HePTP with a k cat /K m of 2.6 ؋ 10 6 M ؊1 s ؊1 . In
doi:10.1074/jbc.m407820200
pmid:15466470
fatcat:zk46mqrck5fcln53xjvw5blx5q