Substance-related disorders (SRD) are associated with various psychosocial factors. Many clinical and social features are observed in SRD, and the symptoms, related legal regulations, and the substances themselves, are strongly affected by cultural and ethnic specificities [1, 2] . In this article, SRD and its surrounding psychosocial problems are discussed in the context of clinical, social, and spiritual elements. This article is based on a qualitative review of current literature addressing SRD, and psychosocial factors related to the topic.