Novel biomimetic ligands were synthesized by the condensation of 3-hydroxyflavone, 2-aminophenol(L 1 )/2-aminobenzoic acid (L 2 ) and-aminothiazole (L 3 ). Their Cu(II) complexes have also been synthesized and characterized on the basis of 1 H NMR, IR, UV-Vis spectra, elemental analyses, molar conductivity, ESR, electrochemical behaviour and thermal analyses. The antimicrobial activities (MIC values) of the ligands, copper complexes and standard drugs have been evaluated using the serial

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... n technique against the bacterial species Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris and Pseudomonas aeruginosa and fungal species Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans. The anti-inflammatory and SOD activities of the investigated compounds are also promising and allow the selection of a lead compound for further biological studies. ª 2011 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).