The intense photoirradiation-induced influence of a photosensitizer, camphorquinone (CQ), contained in light-cured composite resin applied on intraoral tissue is of concern. The difference in cell viability between groups treated with and without light-irradiated culture medium containing CQ was investigated using 3T3 cells, which were used according to the OECD phototoxicity guidelines. A large difference in cell viability was noted between the photoirradiation and non-photoirradiation groups

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... ithin a concentration range of 0.3125~2.5 mg/mL. The influence of phototoxicity was previously not considered in the dental field, but as restoration methods applying intense photoirradiation in the oral cavity, such as light-cured composite resin, are now widely used clinically, the biological influence of intense photoirradiation, even though applied only for a short time, on intraoral tissue must be considered.