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Co-Phosphorylation Networks Reveal Subtype-Specific Signaling Modules in Breast Cancer
[article]
2020
biorxiv/medrxiv
pre-print
Motivation: Protein phosphorylation is a ubiquitous mechanism of post-translational modification that plays a central role in cellular signaling. Phosphorylation is particularly important in the context of cancer, as down-regulation of tumor suppressors and up-regulation of oncogenes by the dysregulation of associated kinase and phosphatase networks are shown to have key roles in tumor growth and progression. Despite recent advances that enable large-scale monitoring of protein phosphorylation,
doi:10.1101/2020.05.04.073148
fatcat:n4uhcja4xrhczoa6fozhfbveie