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Melanin Concentrating Hormone Analogs: Contraction of the Cyclic Structure. III. CD Spectroscopic Study
1992
Collection of Czechoslovak Chemical Communications
A comparison of the CD spectra of MCH analogs differing in length but containing a heterodetic ring of the same size (compounds I, IV and VII or III, VI and IX) reveals that a conformational change occurs upon elongating the peptide chain from thirteen to seventeen amino-acid residues. The 5-17 fragments appear to prefer a β-turn conformation, whereas the 1-17 full-sequence peptides prefer α-helical conformation. Peptides containing seventeen-membered ring exhibit greater conformational
doi:10.1135/cccc19920614
fatcat:x7ueemycz5bhthfyelpl7lswza