Hypophosphatasia in children: Diagnostic problems and treatment prospects

P. V. Novikov
2016 Rossijskij Vestnik Perinatologii i Pediatrii  
The paper gives up-to-date information on hypophosphatasia in children. It represents the results of genetic studies, the pathogene-sis, clinical manifestations, classification, treatment, and prevention of the disease. Particular emphasis is placed on whether clinical trials of novel biological agents for the pathogenetic therapy of hypophosphatasia (enzyme replacement therapy) may be conducted.
doaj:c5aa310e75834807b1482cea28da170c fatcat:xi6squspdrfopopzkxegfswvdy