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Relationship between APO-A, APO-B, and C-reactive Protein with Depression in Epileptic Patients

Diah Kurnia Mirawati, Neurology Department, Dr. Moewardi Regional General Hospital/ Medical Faculty, Universitas Sebelas Maret, Nella Lusti Widhianingsih, Titian Rakhma, Subandi Subandi, Rivan Danuaji, Pepi Budianto, Hanindya Riani Prabaningtyas, Stefanus Erdana Putra, Neurology Department, Dr. Moewardi Regional General Hospital/ Medical Faculty, Universitas Sebelas Maret, Neurology Department, Dr. Moewardi Regional General Hospital/ Medical Faculty, Universitas Sebelas Maret, Neurology Department, Dr. Moewardi Regional General Hospital/ Medical Faculty, Universitas Sebelas Maret (+4 others)
2020 Indonesian Journal of Medicine  

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Epilepsy is one of the oldest neurological disease requiring long-term treat­ment. Long-term use of certain anti-epileptic drugs (AED) will strongly induce cytochrome-P450 (CYP) enzyme resulting increase of homo­cysteine associated with risk of cerebrovascular disease and depression. The purpose of this study was to determine relationship between serum level of ApoA, ApoB, and C-Reactive Protein (CRP) with depression in epileptic patients receiving AED therapy. Subjects and Method: Respondents
more » ... f this cross-sectional study were epileptic outpatients in neurology clinic Dr. Moewardi Hospital, Surakarta receiving AED therapy and met inclusion and exclusion criteria. Depression condition was evaluated by Hamilton Depress­ion Rating Scale (HDRS). Serum level of ApoA, ApoB, and CRP of each respondent were mea­sured from vein blood. Data were analyzed by a multiple linear regression. Results: There were 51 epileptic patients with proportional ratio between men and women (1.2:1) with age range from 18 to 59 years old. The average length of AED 92.67 months (Mean= 92.67; SD= 91.58). Average of HDRS score was 8.49. Meanwhile, average of ApoA level was 86.14 mg/dL, average of ApoB level was 47.57 mg/dL, and average of CRP level was 0.18 mg/dL. Serum level of ApoA, ApoB, and CRP increased depression (HDRS score) in epileptic patients. Conclusion: There was a statistically signi­fi­cant relationship between serum level of ApoA, ApoB, and CRP with depressive condi­tion of epileptic patients receiving long-term AED treatment. Keywords: ApoA, ApoB, C-Reactive Protein, depression, epilepsy
doi:10.26911/theijmed.2020.05.04.03. fatcat:3i27dv3ghzfezl47vhsmmc3vje
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Diah Kurnia Mirawati, Neurology Department, Dr. Moewardi Regional General Hospital/ Medical Faculty, Universitas Sebelas Maret, Nella Lusti Widhianingsih, Titian Rakhma, Subandi Subandi, Rivan Danuaji, Pepi Budianto, Hanindya Riani Prabaningtyas, Stefanus Erdana Putra, Neurology Department, Dr. Moewardi Regional General Hospital/ Medical Faculty, Universitas Sebelas Maret, Neurology Department, Dr. Moewardi Regional General Hospital/ Medical Faculty, Universitas Sebelas Maret, Neurology Department, Dr. Moewardi Regional General Hospital/ Medical Faculty, Universitas Sebelas Maret, Neurology Department, Dr. Moewardi Regional General Hospital/ Medical Faculty, Universitas Sebelas Maret, Neurology Department, Dr. Moewardi Regional General Hospital/ Medical Faculty, Universitas Sebelas Maret, Neurology Department, Dr. Moewardi Regional General Hospital/ Medical Faculty, Universitas Sebelas Maret, Neurology Department, Dr. Moewardi Regional General Hospital/ Medical Faculty, Universitas Sebelas Maret. "Relationship between APO-A, APO-B, and C-reactive Protein with Depression in Epileptic Patients." Indonesian Journal of Medicine 5.4 (2020) 282-290