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The biologically functional identification of a novel TIM3-binding peptide P26 in vitro and in vivo
Cancer Chemotherapy and Pharmacology
Purpose Recent studies have shown that TIM3 plays an important role in T-cell failure, which is closely related to the resistance to anti-programmed cell death protein 1 (PD-1) treatment. However, there have been no reports on the application of peptide blockers to TIM3. In this study, we endeavored to identify the in vitro and in vivo anti-tumor activities of a TIM3-targeting peptide screened from the phage peptide library. Methods Phage display peptide library technology, surface plasmondoi:10.1007/s00280-020-04167-0 pmid:33084973 fatcat:5moyd6umorg73cr5b5wbvxljcm