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We present BITOLA, an interactive literature-based biomedical discovery support system. The goal of this system is to discover new, potentially meaningful relations between a given starting concept of interest and other concepts, by mining the bibliographic database MEDLINE ® . To make the system more suitable for disease candidate gene discovery and to decrease the number of candidate relations, we integrate background knowledge about the chromosomal location of the starting disease as well asdoi:10.1016/j.ijmedinf.2004.04.024 pmid:15694635 fatcat:gaxffooxwnbjxaycy5y74ebjmm