Quinazolinones are heterocyclic components (able to form cyclized compounds) which have several medical effects. They belong to hyponic and potent anticonvulsant drugs, Act strongly, inhibiting human immunodeficiency virus (HIV) and cancer, enter circulatory system and pass through placenta barrier. In this study, for the first time different aspects of developmental effects of 4(3H) quinazlonones-2-ethyl-2-phenyl ethyl (QEPE) on stomach and heart of Balb/C mice embryos were investigated.

more »

... nt Balb/C mice were divided into 3 groups (n= 10) of control, receiving distilled water, sham, receiving 0.05% methyl cellulose (the solvent) and experimental group, receiving one of the most effective dose of 100 mg/kg/body weight of QEPE, by IP injections on day 8th to 15th of gestation. After anesthetizing mothers, stomachs and hearts of 5-day old newborn Balb/C mice were removed, fixed and stained with H & E for light microscopic and quantitative studies. Results showed symptoms of gastritis (hyperaemia and decrease in thickness of mucus layer) in newborn Balb/C mice of treated groups. 4(3H) quinazlonones-2-ethyl-2-phenyl ethyl (QEPE) also created necrotic cells and an increase in connective tissues of hearts of newborn mice of treated groups. In conclusion by being teratogens and toxins, these two new derivatives affected development of embryonic stomach and heart at histological level.