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Phytochemical extraction, optimization and physico-chemical characterization of two bioactive isolates from the leaves and stem of Cissampelos pareira

K Nagarajan, Nithish Chauhan, Ashu Mittal, Vijendar Singh, Ramesh Bodla, Raj Tiwari
2011 Der Pharma Chemica   unpublished

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In the traditional Indian medicine, the roots and leaves of Cissampelos pareira are administered for the relief of diarrhoea and antiseptic against inflammation. The present investigation is to optimize the suitable extraction method and thereby isolating and characterizing various bioactive leads from the leaf and stem portion. Preliminary phytochemical screening reveals the presence of maximum alkaloids and moderate quantity of flavonoids and saponins with dichloromethane as solvent. In leaf
more » ... ortion, the hot extraction method was suited as the alkaloid content seems to be maximum, whereas in stem portion, the cold maceration was suited with more flavonoid content. This was evidenced further with higher yield values obtained for leaf extract (56% w/w) rather than stem extract (39.5% w/w). Two pure bioactive leads were isolated, each one from leaf (
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K Nagarajan, Nithish Chauhan, Ashu Mittal, Vijendar Singh, Ramesh Bodla, Raj Tiwari. "Phytochemical extraction, optimization and physico-chemical characterization of two bioactive isolates from the leaves and stem of Cissampelos pareira." Der Pharma Chemica (2011)