A Stochastic Petri Net-Based Model of the Involvement of Interleukin 18 in Atherosclerosis

Dorota Formanowicz, Agnieszka Rybarczyk, Marcin Radom, Krzysztof Tanaś, Piotr Formanowicz
2020 International Journal of Molecular Sciences  
Interleukin 18 (IL-18) is a proinflammatory and proatherogenic cytokine with pleiotropic properties, which is involved in T and NK cell maturation and the synthesis of other inflammatory cytokines and cell adhesion molecules. It plays a significant role in orchestrating the cytokine cascade, accelerates atherosclerosis and influences plaque vulnerability. To investigate the influence of IL-18 cytokine on atherosclerosis development, a stochastic Petri net model was built and then analyzed.
more » ... , MCT-sets and t-clusters were generated, then knockout and simulation-based analysis was conducted. The application of systems approach that was used in this research enabled an in-depth analysis of the studied phenomenon. Our results gave us better insight into the studied phenomenon and allow revealing that activation of macrophages by the classical pathway and IL-18-MyD88 signaling axis is crucial for the modeled process.
doi:10.3390/ijms21228574 pmid:33202974 pmcid:PMC7696504 fatcat:ss4a2cwpcnfbda4btjzuocxjpa