Objective: The purpose of this study was to analyze the clinical experience of amplitude-integrated electroencephalogram (aEEG) in the neonatal intensive care unit (NICU) and to evaluate the usefulness of the aEEG and to determine whether an EEG could help to identify high risk infants with later epilepsy. Methods: Clinical data of 200 newborn infants admitted to the NICU and monitored with aEEG were reviewed retrospectively. A single-or two-channel aEEG (electrode placement P3-P4 for single,

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... -C4 and P3-P4 for two) was recorded continuously by using gold cups. Background activity was assessed based on voltage and pattern recognition methods. To assess for differences in later epilepsy among infants with abnormal versus normal results, chi-square test was employed with odd ratio. Results: Overall, 200 newborn infants were included. About half showed abnormal findings on aEEG monitoring with 34.5% abnormal background activity, 30.0% abnormal cyclicity, and 30.0% with seizures. The odd ratio for an abnormal trace on aEEG to predict later epilepsy was 7.9 (95% confidence interval; 2.8-22.0; P<0.001). Conclusion: aEEG monitoring is useful for cerebral monitoring in NICU. aEEG monitoring enabled to assess the cerebral integrity of infants by measuring background activities and detecting seizures and help to identify high-risk infant for later epilepsy.