Streptomyces are Gram-positive bacteria known for their production of an enormous variety of biologically active secondary metabolites, including antibiotics, immunosuppressants, and anticancer agents. 1) Streptomyces sp. (YIM 56130) was a plant endophyte from Drymaria diandra. Through the bioactivity screening, this strain was found to show cytotoxicity to HL-60, P388D1 and A549, and show antibacterial activity to Escherichia coli. As a part of our ongoing search for new and potent antitumor

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... tural products from actinomycetes, the chemical investigation on the yeast of this bacterium was carried out. Three new sesquiterpenes (1-3) have been isolated, and their structures were elucidated by two-dimensional (2D)-NMR and high-resolution (HR)-MS as caryolane-1,7a-diol (1), 1,6,11-eudesmanetriol; (1a,6b)form (2), 11-eudesmene-1,6-diol; (1a,6b)-form (3). Nine known compounds were also isolated and elucidated as caryolane-1,9a-diol (4), 2) 2-methyl-5-nonanol (5), 3) soyasaponin I (6), 4) cyclo (Ala-Leu) (7), 5) homononatinic acid (8), 6) bsitosteryl glucoside-3Ј-O-heptadecoicate (9), 7) 2Ј-deoxythymidine (10), 8) 2Ј-deoxyuridine (11), 9) trehalose (12). 10)