CLXXXIX.—Aromatic arsonic acids

Marmaduke Barrowcliff, Frank Lee Pyman, Frederic George Percy Remfry
1908 Journal of the Chemical Society Transactions  
IN a previous communication from these laboratories (Trans., 1908(Trans., , 93, 1180,~some account was given of the preparation and properties of certain aromatic arsonic and arsinic acids, and reference was made to the use of substances of this class in trypanosomiasis. A t that time, the physiological results obtained with the bis-aminoarylarsinic acids were not sufficiently conclusive for publication, but Dr. Breinl has now found that sodium bis-2-aminotolyl-5-arsinate and sodium
more » ... sodium bis-2acetylaminotolyl-5-axsinate are of little use in trypanosomiasis, probably owing to their low arsenic content. The present communication records the chemical and physical properties of a number of new arsonic acids, which are derivatives of p-aminophenylarsonic acid and 2-aminotolyl-5-arsonic acid. These two acids have, of course, a certain toxicity, although this is only a small fraction of that of arsenic acid, and it was thought at one time that they were slowly decomposed in the body with formation of arsenic acid and aniline or o-toluidine respectively, and that their toxicity was due partly t o the arsenic acid and partly to the aniline. We therefore prepared p-hydroxyphenykarsonic acid and 2-hydroxytolyl-6-arsonic acid by diazotising the corresponding amino-acids and removing the nitrogen, in order that when the arsonic acid was decomposed in the body, phenol and o-cresol should result instead of
doi:10.1039/ct9089301893 fatcat:qxs6pyy3azbtvobkafni5zfn7y