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Canonical mechanisms of protein evolution include the duplication and diversification of pre-existing folds through genetic alterations that include point mutations, insertions, deletions, and copy number amplifications, as well as post-translational modifications that modify processes such as folding efficiency and cellular localization. Following a survey of the human mutation database, we have identified an additional mechanism, that we term 'structural capacitance', which results in the dedoi:10.1101/269613 fatcat:262odgy2vvbwxp3724bhef5nc4