Antibody Fragments Defining Biologically Relevant Conformations of Target Proteins

Alastair Lawson
2014 Antibodies  
Antibody fragments have long been used as chaperones in crystallography, but have more recently been applied to the definition of biologically relevant conformations among the dynamic ensemble of target protein conformational sampling. This review charts the progress being made in understanding function in the context of structure using this approach, and highlights new opportunities for drug discovery.
doi:10.3390/antib3040289 fatcat:wog76krydndz5bbpzvvcg47aza