Transfusion Management of a Patient with IgA Deficiency

Ranu Jain
2019 Global Journal of Pediatrics & Neonatal Care  
Immunoglobulin (Ig) A deficiency is the most common primary immunodeficiency characterized by a decreased serum level of IgA in the presence of normal serum levels of other immunoglobulin isotypes. Patients with severe IgA deficiency may experience transfusion reactions when administered blood products that are not IgA deficient. There are complexities involved in organizing safe transfusion support, especially when the specific timing and transfusion needs of the procedure are unpredictable.
more » ... re unpredictable. While a history of IgA deficiency is certainly not a contraindication to surgical procedures requiring blood or blood product transfusions in the perioperative period, careful planning and a multidisciplinary approach are paramount in ensuring successful treatment as well as patient safety.
doi:10.33552/gjpnc.2019.01.000524 fatcat:ibd4x5jmane6vbcyn5ygv23hxq