Background/Aim. Bronchiolitis in early childhood caused by respiratory syncytial virus (RSV) is considered to be important risk factor of the recurrent wheezing and asthma development. The aim of this study was to examine the frequency of RSV infection and atopy in children up to two years of age and to determine their correlation with bronchial hyperreactivity. Methods. The study included 175 children aged 5-24 months. The presence of RSV infection was identified by serum levels of IgA and IgG

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... determined by ELISA. Bronchial hyperreactivity (BHR) has been defined as the existence of chronic bronchial disease and/or three or more previous suspected diagnosis of acute bronchial disease. Atopy was confirmed by detection of the specific serum IgE using quantitative multitest Phadiatop infant (cut off ≥ 0.35 kUA/L). Results. The children with atopy were more frequently infected with RSV (43.3%) than those without atopy (22.8%; p = 0.02). The higher frequency of RSV infection was found in children with BHR in comparison with those without it but only in the group who also had atopy (77.8% vs 28.6%, p = 0.018). In the female children, BHR and RSV infection were associated in 62.5% of cases, regardless the atopy. In the male children with atopy, RSV infection was associated with BHR in 83.3% of the cases, while in those without atopy, RSV infection with BHR was found in only 17.4% of the cases. Conclusion. Children up to two years of age with atopy are more frequently infected with RSV (43.3%) than non-atopic children. Every third child with atopy develops BHR and 77.8% of them also have RSV infection. Atopic children are at higher risk for development of BHR when infected with RSV also. Apstrakt Uvod/Cilj. Bronholitis u ranom detinjstvu izazvan respiratornim sincicijalnim virusom (RSV), smatra se značajnim faktorom rizika od pojave rekurentnog vizinga i astme. Cilj ovog rada bio je da se ispita učestalost RSV infekcije i atopije kod dece uzrasta do dve godine i da se ustanovi njihova korelacija sa bronhijalnom hiperreaktivnošću (BHR). Metode. U istraživanje je bilo uključeno 175 dece uzrasta od 5 do 24 meseca. Prisustvo RSV infekcije je ustanovljeno na osnovu serumske koncentracije anti-RSV IgA i IgG antitela određenih ELISA testom. Hiperreaktivnost bronhijalnog stabla (BHR) je definisana kao postojanje hronične bronhijalne bolesti i/ili tri i više prvih kurativnih pregleda pod dijagnozom akutne bronhijalne bolesti. Postojanje atopije utvrđeno je detekcijom serumskih specifičnih IgE antitela kvalitatitvnim multitestom Phadiatop infant (≥ 0,35 kUA/L). Rezultati. Deca sa atopijom češće su imala RSV infekciju (43,3%) nego deca bez atopije (22,8%; p = 0,02). Veća učestalost RSV infekcije kod dece sa BHR u odnosu na decu bez BHR postojala je samo u grupi atopičara (77,8% vs 28,6%; p = 0,018). Ženska deca imala su udruženost BHR i RSV infekcije u 62,5% slučajeva bez obzira na atopiju. Kod muške deca sa atopijom RSV infekcija bila je udružena sa BHR kod 83,3%, dok je kod muške dece bez atopije to bio slučaj kod samo 17,4% slučajeva. Zaključak. Deca uzrasta do dve godine sa atopijom češće su imala RSV infekciju (43,3%) nego deca bez atopije. Svako treće dete sa atopijom imalo je BHR, pri čemu je 77,8% imalo i RSV infekciju. Deca sa atopijom koja imaju RSV infekciju su u većem riziku od razvoja BHR. Ključne reči: respiratorni sincicijalni virusi; bronhusi, bolesti; hipersenzibilnost, rana; komorbiditet; deca; srbija.