P193 A role for active Vitamin D in steroid resistant asthma patients who have enhanced production of IL-17A and reduced IL-10

AM Nanzer, ES Chambers, DF Richards, AR Martineau, CJ Griffiths, C Corrigan, CM Hawrylowicz
2013 Thorax  
function (FEV1, FEF25-75, total airway resistance at 5Hz: R5) and on salbutamol FEV1 recovery post histamine challenge. Comparisons were made between genotypes comprising one or two copies of Arg (i.e. ArgArg or ArgGly n = 15, FEV1 = 91.1%, FEF25-75 = 58.3%) vs. no copies of Arg (i.e. GlyGly n = 10, FEV1 = 94.1% FEF25-75 = 60.0%). Results Data are shown in table as change from baseline (i.e. pre vs. post propranolol as means and SEM) within each genotype. Within the Arg genotype there were
more » ... ficant effects of propranolol on FEV1, FEF25-75 and R5 as well as significant blunting of salbutamol response, while in the Gly genotype only salbutamol response was significant. However when comparing the Arg vs. Gly genotypes there were no significant differences for any of the outcomes. Conclusion Propranolol produces significant effects on pulmonary function and salbutamol response in the Arg genotype, although there were no significant differences between Arg and Gly genotypes.
doi:10.1136/thoraxjnl-2013-204457.345 fatcat:7qdhhneeibhgdgovttfrrtkaqy