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AB0151 Characterization of the plasmatic glycoprotein and lipoprotein profiles of systemic lupus erythematosus by nuclear magnetic resonance spectroscopy
2018
SLE, Sjögren's and APS – etiology, pathogenesis and animal models
unpublished
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Conclusions: The data suggest that activation of B cells from SLE patients require CD40/CD40L interaction to increase PD-L1 expression, which is, however, reduced compared to HD. Diminished PD-L1 expression upon B cell stimulation is consistent with impaired inhibition of T cells in SLE (figure 1). REFERENCES: [1] Nishimura H, et al. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999;11(2):141-151. [2]
doi:10.1136/annrheumdis-2018-eular.3500
fatcat:2fgoe6ewafc47mopowq3sikydm